CMA 12 Microdialysis Probes

Ideal for stereotaxic work in the CNS of anesthetized or conscious animals.

  • Optimized for CNS use
  • Ideal for chronic implantation
  • Available membranes: PAES, 20 kDA MWCO or PES, 100 kDA MWCO
  • Membrane lengths: 1, 2, 3 or 4 mm
  • Membrane diameter: 0.5 mm
  • Available metal free

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The CMA 12 Microdialysis Probe is ideal for stereotaxic work in the CNS of anesthetized or conscious animals.

A semi-permeable membrane is glued between the tip of the inner steel cannnula and the outer steel shaft. The perfusion fluid enters the membrane space through two holes in the inner cannula and flows into the shaft to the outlet.

All metal parts are treated to prevent oxidation of labile compounds in the perfusate. The membrane is available in both 20,000 and 100,000 Daltons cut-offs as standard. The inlet/outlet capillaries are mounted in a blue plastic body matched to the size of a corresponding CMA 12 guide cannula.

Once implanted, the probe sits tightly in the guide cannula.

CMA 12 Microdialysis Probe

 

Ordering Information

Product Name Item #
CMA 12 Elite Probe, 1 mm membrane length, pkg. of 3 CMA8010431
CMA 12 Elite Probe, 2 mm membrane length, pkg. of 3 CMA8010432
CMA 12 Elite Probe, 3 mm membrane length, pkg. of 3 CMA8010433
CMA 12 Elite Probe, 4 mm membrane length, pkg. of 3 CMA8010434
CMA 12 HighCO Probe, 1 mm membrane length, pkg. of 3 CMA8309661
CMA 12 HighCO Probe, 2 mm membrane length, pkg. of 3 CMA8309662
CMA 12 HighCO Probe, 3 mm membrane length, pkg. of 3 CMA8309663
CMA 12 HighCO Probe, 4 mm membrane length, pkg. of 3 CMA8309664
CMA 12 Elite Metal Free Probe, 1 mm membrane length, pkg. of 3 CMA8011201
CMA 12 Elite Metal Free Probe, 2 mm membrane length, pkg. of 3 CMA8011202
CMA 12 Elite Metal Free Probe, 3 mm membrane length, pkg. of 3 CMA8011203
CMA 12 Elite Metal Free Probe, 4 mm membrane length, pkg. of 3 CMA8011204
CMA 12 HighCO Metal Free Probe, 1 mm membrane length, pkg. of 3 CMA8011221
CMA 12 HighCO Metal Free Probe, 2 mm membrane length, pkg. of 3 CMA8011222
CMA 12 HighCO Metal Free Probe, 3 mm membrane length, pkg. of 3 CMA8011223
CMA 12 HighCO Metal Free Probe, 4 mm membrane length, pkg. of 3 CMA8011224

 

Downloads

CMA 12 Elite Probes User’s Manual
CMA 12 High CO Probes User’s Manual
2016 CMA Microdialysis Catalog
CMA Microdialysis Probes Catalog

 

Journal Articles

Selected Recent Publications

Paasonen, J. et al., 2017. Dose-response effect of acute phencyclidine on functional connectivity and dopamine levels, and their association with schizophrenia-like symptom classes in rat. Neuropharmacology, 119, pp.15–25.

Kealy, J. et al., 2017. Real-time changes in hippocampal energy demands during a spatial working memory task. Behavioural Brain Research, 326, pp.59–68.

Alves, I.A. et al., 2017. Influence of Experimental Cryptococcal Meningitis in Wistar Rats on Voriconazole Brain Penetration Assessed by Microdialysis. Antimicrobial Agents and Chemotherapy, p.AAC.00321-17.

Jin, W.-S. et al., 2017. Peritoneal dialysis reduces amyloid-beta plasma levels in humans and attenuates Alzheimer-associated phenotypes in an APP/PS1 mouse model. Acta Neuropathologica, pp.1–14.

Kurosawa, T. et al., 2017. Involvement of Proton-Coupled Organic Cation Antiporter in Varenicline Transport at Blood-Brain Barrier of Rats and in Human Brain Capillary Endothelial Cells. Journal of Pharmaceutical Sciences, 0(0). Available at: http://jpharmsci.org/article/S0022-3549(17)30267-8/abstract [Accessed May 14, 2017].

Bank, J.H.H. et al., 2017. Gene expression analysis and microdialysis suggest hypothalamic triiodothyronine (T3) gates daily torpor in Djungarian hamsters (Phodopus sungorus). Journal of Comparative Physiology B, pp.1–12.

Miller, S. et al., 2017. Therapeutic Uses Of Compounds Having Affinity To The Serotonin Transporter, Serotonin Receptors and Noradrenalin Transporter. Available at: http://www.freepatentsonline.com/y2017/0087138.html [Accessed May 14, 2017].

Wang, W. et al., 2017. Effect of Efflux Transporter Inhibition on the Distribution of Fluconazole in the Rat Brain. Neurochemical Research, pp.1–8.

Mørk, A. et al., 2017. Effects of the 5-HT6 receptor antagonist idalopirdine on extracellular levels of monoamines, glutamate and acetylcholine in the rat medial prefrontal cortex. European Journal of Pharmacology, 799, pp.1–6.

Takeda, A. et al., 2017. Characteristic of Extracellular Zn2+ Influx in the Middle-Aged Dentate Gyrus and Its Involvement in Attenuation of LTP. Molecular Neurobiology, pp.1–11.

SKU: CMA 12 Category: Tags: , ,
Probe Name CMA 12 Elite CMA 12 High Cut-off
Membrane Length 1, 2, 3 and 4 mm 1, 2, 3 and 4 mm
Membrane Diameter 0.5 mm 0.5 mm
Membrane Material PAES PES
Molecular Weight Cut Off 20 kDa 100 kDa
Shaft Diameter 0.64 mm 0.64 mm
Shaft Length 14 mm 14 mm
Inlet Internal Volume Negligible Negligible
Outlet Volume 0.3 µL 0.3 µL