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TSE Inhalation System
Precision Inhalation Systems for Diverse Applications
Drawing on over 40 years of experience, TSE are a leading manufacturer of in-vivo and in-vitro inhalation systems renowned for their precision and reliability. Their commitment extends beyond core systems by providing the scientific community with the widest range of substance delivery and analysis modules. This modularity empowers researchers to customize studies and address a broad spectrum of research needs.
German Engineering for Exceptional Performance: TSE systems uphold precision engineering principles, ensuring exquisite accuracy and consistent data generation. This translates to robust and reliable research outcomes in diverse areas, including pharmacology, toxicology, environmental safety assessment and occupational health studies.
Expert Guidance for Compliant Studies: TSE recognize that successful inhalation studies require a holistic approach. Beyond equipment, Linton and TSE offer dedicated scientific consultations to ensure your study design meets regulatory guidelines, such as OECD, EPA, and GLP.
Selection of Available Modules |
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Exposure units |
Analysis equipment |
Environmental Control |
| Cell Cultures | Concentration Measuring Unit. | Pressure Sensors |
| Head-Nose Towers | Cascade Impactor | Temperature Sensor |
| Whole Body Chambers | Particle Size Distribution | Oxygen and Carbon Dioxide Sensors |
| Large Animals Exposure Units | Nanoparticle Size Distribution | Humidity Sensor |
Test Substances |
Animal species |
Essentials |
| Liquid Aerosol | Rodents | Safety Cabinets and Hoods |
| Dust Aerosol | Dogs | Humidity Control System |
| Vapor | Monkeys | 3-stage Exhaust air Filtration |
| Nanoparticles | Non-Human Primates | Alarm Module |
Head-Nose Exposure TowersModular Configuration: We offer a range of Head-Nose exposure towers specifically designed for inhalation studies in rodents and large laboratory animals, like dogs or non-human primates. These towers feature a modular design, allowing researchers to configure the system for studies involving 8 to 96 animals simultaneously. Large animal towers offer adaptability, allowing exposure and real-time individual concentration analysis for up to 4 animals at a time. Flow-Through Design: The towers employ a sophisticated flow-pass design that guarantees uniform distribution of test substances throughout the exposure unit and avoiding an exhaled air rebreathing. This ensures consistent exposure across all animals within the system, minimizing confounding variables and enhancing data quality. Environmental Monitoring: Beyond exposure control, our towers offer the option to integrate environmental sensors for real-time monitoring of critical parameters. These sensors measure temperature, humidity, oxygen (O2) and carbon dioxide (CO2) levels, and pressure. This monitoring plays a vital role in maintaining experiment integrity and optimizing animal welfare. |
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Our System Modular and Extendable Architecture.
Together we are working on system configuration to meet study design requirements, safety assessment protocols and methodologies for measuring the properties of the tested substances.
Benefits
| Standard or Customized Modular Systems | Various Species from Rodents to Large animals | German Precision Engineering |
| Complete Automation and Control | Software and Documentation for GLP Validation | Validation Documentation including IQ, OQ |
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NEW Table Top SystemIntroducing new Head-Nose exposure unit that fits size requests and budget constraints. Its modular design meets diverse experimental needs. The compact system seamlessly integrates within existing fume hoods, facilitating efficient exhaust management and exposure control. This capability is particularly valuable for studies utilizing volatile or hazardous test substances. Our Table Top system’s modularity extends to its scalable capacity, accommodating studies with 8 to 26 rodents. This flexibility allows researchers to tailor the exposure environment to the specific requirements of their investigation. Additionally, the lower internal volume minimizes the amount of test substance required for effective exposure, promoting cost-efficiency during studies. Modular design ensures a streamlined and time-saving setup process, allowing researchers to initiate studies more efficiently. Streamline preclinical inhalation studies with modular design, high-precision exposure, and efficient substance utilization. |
Support
| Safety operation features and tools for setting alarm and automatic shutdown. |
Chemically resistant parts for aggressive substances |
Integration of external equipment for substance generation and analysis |
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Training and Scientific Support including application training. |
Comprehensive Calibration: we offer calibration kits to maintain accuracy and reliability in substance delivery. |
Preventive maintenance 24/7 Service Hotline – round the clock for you |
Publications
Toxicokinetic assessment of inhaled silvr nanoparticles using particle number as metric and oxidative stress measurements.
Andriamasinoro, S. N., Serventi, A. M., Veillette, R., Dieme, D., Haddad, S., & Bouchard, M. (2023).
Human distal airways contain a multipoten secretory cell that can regenerate alveoli.
Basil, M. C., Cardenas-Diaz, F. L., Kathiriya, J. J., Morley, M. P., Carl, J., Brumwell, A. N., Katzen, J., Slovik, K. J., Babu, A., Zhou, S., Kremp, M. M., McCauley, K. B., Li, S., Planer, J. D., Hussain, S. S., Liu, X., Windmueller, R., Ying, Y., Stewart, K. M., … Morrisey, E. E. (2022).
Co-exposure to urban particulate matter and aircraft noise adversely impacts the cerebro-pulmonary-cardiovascular axis in mice.
Kuntic, M., Kuntic, I., Krishnankutty, R., Gericke, A., Oelze, M., Junglas, T., Bayo Jimenez, M. T., Stamm, P., Nandudu, M., Hahad, O., Keppeler, K., Daub, S., Vujacic-Mirski, K., Rajlic, S., Strohm, L., Ubbens, H., Tang, Q., Jiang, S., Ruan, Y., … Münzel, T. (2023).
Periodontitis contributes to COPD progression via affecting ferroptosis.
Xiong, K., Yang, P., Wei, W., Li, J., Cui, Y., Li, Y., & Tang, B. (2023).
Whole-body nanoparticle Aerosol Inhalation Exposures.
Yi, J., Chen, B. T., Schwegler-Berry, D., Frazer, D., Castranova, V., McBride, C., Knuckles, T. L., Stapleton, P. A., Minarchick, V. C., & Nurkiewicz, T. R. (2013).
Center of Knowledge
Inhalation system in Mainz – Video
Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System – Video
DACO GLP Software – Flyer
