Inhalation - TSE
Cigarette Smoke Generators
Continuous smoking of cigarettes for inhalation exposures
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Cigarette Smoke Generators
Continuous smoking of cigarettes for inhalation exposures
TSE Systems offers two types of Cigarette Smoke Generators:
- The fully automatic 10-port Cigarette Smoke Generator is used for continuous smoking of cigarettes for chronical inhalation exposure tests. This generator offers automatic filling, igniting, smoking, ejecting, and reloading of cigarettes through our SMG software. The proper operation status – butt length, cigarette loading, number of burning cigarettes, etc. – is monitored by sensitive and specially configured sensors.
- The semi-automatic 2-port Cigarette Smoke Generator is used for short exposures of cigarette smoke and small nose only and cell culture exposure systems.
Both cigarette smoke generators offer a smoking routine and puff profile according to DIN ISO 3308 and other protocols.
Features
- Continuous cigarette smoking for several hours
- Cigarette magazine for up to 200 cigarettes for continuous reloading during operation
- For use with research cigarettes and standard cigarettes of different sizes and diameters
Selected Publications
Stanford D, Kim H, Bodduluri S, LaFontaine J, Byzek SA, Schoeb TR, Harris ES, Nath HP, Bhatt SP, Raju SV, Rowe SM. Airway Remodeling in Ferrets with Cigarette Smoke Induced COPD using µCT Imaging. Am J Physiol Lung Cell Mol Physiol. 2020 May 6;319(1):L11–20.
Yogesh Saini Noël, Ingeborg Langohr, Sonika Patial, Arthur L. Penn and Brandon W. Lewis, Razia Sultana, Rahul Sharma, Alexandra. Lung Disease Immune Responses in Muco-Obstructive Disrupts Bacterial Clearance and Abolishes Early Postnatal Secondhand Smoke Exposure. Immunol 2017; 199:1170-1183
Selected Product Citations
Airway remodeling in ferrets with cigarette smoke-induced COPD using µCT imaging |
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| Denise Stanford, Harrison Kim, Steven M.Steven M. Rowe Rowe | Am J Physiol Lung Cell M | Published 1 Jul 2020 |
| Article Snippet Abstract: Structural changes to airway morphology, such as increased bronchial wall thickness (BWT) and airway wall area, are cardinal features of chronic obstructive pulmonary disease (COPD). Ferrets are a recently established animal model uniquely exhibiting similar clinical and pathological characteristics of COPD as humans, including chronic bronchitis. Our objective was to develop a microcomputed tomography (µCT) method for evaluating structural changes to the airways in ferrets and assess whether the effects of smoking induce changes consistent with chronic bronchitis in humans. Ferrets were exposed to mainstream cigarette smoke or air control twice daily for 6 mo. µCT was conducted in vivo at 6 mo; a longitudinal cohort was imaged monthly |
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Early Postnatal Secondhand Smoke Exposure Disrupts Bacterial Clearance and Abolishes Immune Responses in Muco-Obstructive Lung Disease. |
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| Brandon W Lewis, Razia Sultana, …, Yogesh Saini | J Immunol | Published 30 Jun 2017 |
| Article Snippet SHS exposures were conducted at the American Association for the Accreditation of Laboratory Animal Care–accredited Inhalation Facility at Louisiana State University.. We used a TSE Cigarette Smoke Generator (TSE Systems, Chesterfield, MO) to generate SHS from 3R4F filtered research cigarettes (University of Kentucky, Lexington, KY).. HEPA-filtered air (FA) or SHS in FA was supplied to 1.3-m3 Plexiglas exposure chambers fitted with stainless steel wire cages (17). |
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A new experimental model of cigarette smoke-induced emphysema in Wistar rats *A new experimental model of cigarette smoke-induced emphysema in Wistar rats * **Um novo modelo experimental murino de enfisema: enfisema induzido pela fumaça do cigarro em ratos Wistar |
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| Rodrigo de las Heras Kozma, Edson Marcelino Alves, …, João Tadeu Ribeiro-Paes | J Bras Pneumol | Published 30 Jul 2013 |
| Article Snippet Discussion Cigarette smoke-induced emphysema has been studied under various experimental conditions. ( , , , , , ) Although some questions remain regarding the duration of exposure and the number of cigarettes used, animal models of cigarette smoke-induced emphysema are the experimental models that best mimic the clinical features of pulmonary emphysema in human patients and constitute an important tool in the study of the pathophysiological aspects of the disease. ( ) Although animal models of cigarette smoke-induced emphysema have been used in several studies, only a few smoke exposure systems are commercially available, including the Cigarette Smoke Generator(r) (TSE Systems, Inc., Chesterfield, MO, USA), the TE-2 Smoking Machine(r) (Teague Enterprises, Woodland, CA, USA), and the inExposeTM (SCIREQ).. All have similar characteristics, consisting of a cigarette smoke.. |
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