Anipill®
Innovative solution for reliable accurate and continuous core temperature monitoring of many animal species.
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Why choose Anipill® ?
Developed by physiologists, the solution was designed to combine comfort and ease of use. It ensures complete data collection and help to solve many challenges in animal research:
- Preserve animal mobility and social living conditions
- Promote animal welfare by limiting handling, stress and constraints applied to the animals
- Help to reduce the number of animals used and the costs of studies by collecting reliable and continuous data.
Anipill®, an additional asset for your experimentations
The temperature variable is a key indicator of the animal physiological status. The continuous nature of the measurement is more difficult to obtain and only a few restrictive devices (rectal probes, etc.) allow continuous core temperature monitoring.
Anipill® is a miniaturized electronic capsule that can be ingested in medium-sized species or simply implanted in small animals such as mice (from 20 grams).
- Real-time communication technology allows you to have continuous access to the data collected with a dedicated monitor, Anilogger®, which also stores the data.
- The internal memory integrated to the capsule guarantees the recovery of all the data collected both in case of communication breakdown with the monitor and during measurements in extreme conditions. The synchronization of the data a posteriori thus makes it possible to recover all the temperature kinetics, without any data loss.
- The capsule has a 20 days to 10 months life duration, depending on the sampling period choose. The capsule is delivered sterilized and deactivated.
- An activation box allows to wake up the Anipill® capsule and associate it with the Anilogger® monitor.
- A single monitor can manage up to 8 capsules simultaneously.
A dedicated interface, PC and MAC compatible, retrieves data for archiving or clinical use.
Applications: Various use cases
The Anilogger® solution allows continuous core temperature monitoring of the animals for the purpose of understanding physiological mechanisms or to control the physiological status of the animal. The device is suitable for data collection in pharmacology / vaccinology but also for biological rhythms, hibernation, or thermoregulation processes analysis.
Pharmacological studiesCore temperature monitoring in infectiology and/or virology is crucial; kinetics analysis helps to better understand how an active substance, a therapy or a pathology impacts the animal’s ability to regulate its temperature. |
HibernationHibernation is a biological condition in which the vital functions of the animal are kept in a minimal state; this corresponds to a period of deep sleep during which the animal undergoes a series of physiological changes (hypothermia, slowing down of essential functions, …) during the winter. |
Biological
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Thermoregulation
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Scientific publications
| Guisle et al., (2020) Circadian and sleepwake dependent variations in tau phosphorylation are driven by temperature |
| Van der Vinne et al., (2019) Maximising survival by shifting the daily timing of activity. |
| Schulze et al., (2018) Body temperature of bitches in the first week after parturition measured by ingestible loggers |
| Tattersall et al., (2016) Novel energy-saving strategies to multiple stressors in birds: the ultradian regulation of body temperature. |
| Calonne et al 2019 Low 24-hour core body temperature as a thrifty metabolic trait driving catch-up fat during weight regain after caloric restriction |
| Rufiange et al 2020, Pre-warming before general anesthesia with isoflurane delays the onset of hypothermia in rats |
| Meyer et al, 2017 Body Temperature Measurements for Metabolic Phenotyping in Mice |
| Menneson et al 2019, Validation of a Psychosocial Chronic Stress Model in the Pig Using a Multidisciplinary Approach at the Gut-Brain and Behavior Levels |
| Mai et al, 2020 Effect of non-thermal radiofrequency on body temperature in mice |
| Laperrousaz et al, 2018 Lipoprotein Lipase Expression in Hypothalamus Is Involved in the Central Regulation of Thermogenesis and the Response to Cold Exposure |
| Gill et al 2016, PGC-1α expression in murine AgRP neurons regulates food intake and energy balance |
Anipill® capsule |
|
| Shelf storage | 2 years |
| Weight | 1,7g |
| Size | 17,7mm x 8,9mm |
| Sampling period | 1min, 2min, 5min, 15min, 1h |
| Life duration | 20 days to 10 months |
| Accuracy | 0.2°C |
| Calibration | 25°C to 45°C |
| FIFO memory with a 2000 data capacity | |
| Data transmission | RF communication (433 MHz) |
| Communication range | 1- 3m (depending on species |
Anilogger® monitor |
|
| Up to 8 capsules per monitor | |
| Multichannel | 7 monitors in parallel |
| Storage | 150 000 data per capsule |
| Autonomy | 24/36h |
| Size | 120mm x 70mm x 15mm |