CaloTreadmill

The TSE CaloTreadmill System is a fully computerized electronically controlled system to investigate exercise calorimetry in mice and rats. CaloTreadmills are enclosed by an air-tight transparent housing that can be connected to a fully automated indirect gas calorimetry system (CaloSys) operated by PhenoMaster software. Calorimetric parameters, such as oxygen consumption (VO2), carbon dioxide production (VCO2), respiratory exchange rate (RQ) and energy expenditure (EE) are determined at fixed temporal intervals while the test animal is moving according to an experimenter-defined activity profile.

Selected Publications

Hingst JR, Kjøbsted R, Birk JB, Jørgensen NO, Larsen MR, Kido K, Larsen JK, Kjeldsen SAS, Fentz J, Frøsig C, Holm S, Fritzen AM, Dohlmann TL, Larsen S, Foretz M, Viollet B, Schjerling P, Overby P, Halling JF, Pilegaard H, Hellsten Y, Wojtaszewski JFP. Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise. Mol Metab 2020; 40: 101028.

Slater RE, Strom JG, Methawasin M, Liss M, Gotthardt M, Sweitzer N, Granzier HL. Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance. J Gen Physiol 2019; 151(1): 42-52.

Brynnel A, Hernandez Y, Kiss B, Lindqvist J, Adler M, Kolb J, van der Pijl R, Gohlke J, Strom J, Smith J, Ottenheijm C, Granzier HL. Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy. Elife 2018; 7: e40532.

Molinero A, Fernandez-Perez A, Mogas A, Giralt M, Comes G, Fernandez-Gayol O, Vallejo M, Hidalgo J. Role of muscle IL-6 in gender-specific metabolism in mice. PLoS One 2017; 12(3):e0173675.

Cavalera M, Axling U, Berger K, Holm C. Rose hip supplementation increases energy expenditure and induces browning of white adipose tissue. Nutr Metab (Lond) 2016; 13:91.

Fentz J, Kjøbsted R, Birk JB, Jordy AB, Jeppesen J, Thorsen K, Schjerling P, Kiens B, Jessen N, Viollet B, Wojtaszewski JF. AMPKα is critical for enhancing skeletal muscle fatty acid utilization during in vivo exercise in mice. FASEB J 2015; 29(5): 1725-38.

Selected Product Citations

Rose hip supplementation increases energy expenditure and induces browning of white adipose tissue
Michele Cavalera, Ulrika Axling, …, Cecilia Holm	Nutr Metab Lond | Published 6 Dec 2016
Article Snippet Whole-body energy metabolism, food and water intake as well as voluntary locomotor and wheel activity were measured with PhenoMaster/LabMaster Home cage System (TSE-systems, Germany).. The experiment was performed with a CaloTreadmill (TSE systems – Germany) set at a 20% inclination after a four-day training.. EE, oxygen and carbon dioxide fractions were continuously monitored and the respiratory exchange ratio (RER) was calculated.