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NeuroLux – Optogenetics
Battery-free wireless optogenetics implants
NeuroLux system provides tools with no external antennas, batteries, fiber optic cables, or head mount. The implants have an ultra lightweight construction (0.02 g), which allows subjects to move naturally as individuals or as interacting members of social groups.
With NeuroLux user-friendly GUI, researchers can select wavelength and program pulse frequency and duration for optogenetics stimulation/inhibition. Multiple colors for LEDs are also available to study various behaviors. Better yet, our system is compatible with any TTL input system.
With the wireless battery-free operation, NeuroLux implants have unlimited operational lifetimes. The thin, flexible form factors allow the device to affix on top of the subject’s skull for up to fourteen months. NeuroLux platform provides low-cost hardware packages that are customizable to meet the needs of any laboratory environments. The technology is simple and easy to use, which bypasses the need to invest in and learn how to operate the standard optoelectronic hardware.
Unilateral Device |
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The brain implantable device mounts sub-dermally on top of the animal’s skull for chronic stability in operation without any observable adverse effects on the animal movement, brain tissue, or general social behavior. It also incorporates a red indicator LED to provide a convenient indicator of operation.
Size: 10.5 x 1.3 mm (diameter x thickness) LED probe length: 2, 4, 6 mm |
Bilateral Device |
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The newly released bilateral device mounts sub-dermally on top of the animal’s skull, incorporating two probes with a uLED on each end to deliver simultaneous bilateral stimulations into two distinctive target regions.
Size: 11.5 x 10.5 x 1.3 (L x W x thickness) LED probe length: 2, 4, 6 mm |
Spinal Device |
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The spinal device flexibility, lightweight construction, and open oblong design with a single µ-LED tethered centrally at the probe tip allow for easy manipulation and robust operation.
Size: 10 x 5 x 1.3 mm (L x W x thickness) |
Features
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Wireless battery-free operation
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Customizable hardware packages
Compatible with
Selected Publications
Ausra, J., Munger, S. J., Azami, A., Burton, A., Peralta, R., Miller, J. E., & Gutruf, P. (2021). Wireless battery free fully implantable multimodal recording and neuromodulation tools for songbirds. Nature Communications, 12(1), 1968. https://doi.org/10.1038/s41467-021-22138-8
Ausra, J., Wu, M., Zhang, X., Vázquez-Guardado, A., Skelton, P., Peralta, R., Avila, R., Murickan, T., Haney, C. R., Huang, Y., Rogers, J. A., Kozorovitskiy, Y., & Gutruf, P. (2021). Wireless, battery-free, subdermally implantable platforms for transcranial and long-range optogenetics in freely moving animals. Proceedings of the National Academy of Sciences, 118(30). https://doi.org/10.1073/pnas.2025775118
Burton, A., Obaid, S. N., Vázquez-Guardado, A., Schmit, M. B., Stuart, T., Cai, L., Chen, Z., Kandela, I., Haney, C. R., Waters, E. A., Cai, H., Rogers, J. A., Lu, L., & Gutruf, P. (2020). Wireless, battery-free subdermally implantable photometry systems for chronic recording of neural dynamics. Proceedings of the National Academy of Sciences, 117(6), 2835–2845. https://doi.org/10.1073/pnas.1920073117
Gutruf, P., Krishnamurthi, V., Vázquez-Guardado, A., Xie, Z., Banks, A., Su, C.-J., Xu, Y., Haney, C. R., Waters, E. A., Kandela, I., Krishnan, S. R., Ray, T., Leshock, J. P., Huang, Y., Chanda, D., & Rogers, J. A. (2018). Fully implantable optoelectronic systems for battery-free, multimodal operation in neuroscience research. Nature Electronics, 1(12), 652–660. https://doi.org/10.1038/s41928-018-0175-0
Hibberd, T. J., Feng, J., Luo, J., Yang, P., Samineni, V. K., Gereau, R. W., Kelley, N., Hu, H., & Spencer, N. J. (2018). Optogenetic induction of colonic motility in mice. Gastroenterology, 155(2), 514-528.e6. https://doi.org/10.1053/j.gastro.2018.05.029
