PhenoWorld
Colony Housing Automatised Behavioural Phenotyping
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PhenoWorld
Colony Housing Automatised Behavioural Phenotyping
PhenoWorld is a unique combination approach that integrates the functionality of a variety of automated phenotyping systems into one multidimensional setup level. The complete system is operated by one master software that operates all modules, synchronizes, and integrates all incoming data allowing fully automated experimentation without human interference.
Behavior, cognition, metabolism and physiology modules from the TSE PhenoMaster and IntelliCage can be implemented into multiple homes or satellite cages or maze, which are strategically interconnected. Multiple paradigms can be combined and/or run at the same time.
In PhenoWorld, animals live in social groups, which allows them to develop and display species-specific natural social behavior – a prerequisite for animal welfare and high translational value of experimental data. Every animal is tagged with an RFID transponder and is recognized for individualized data acquisition.
Animals travel between PhenoWorld compartments and levels through a number of different gating structures: (1) automated Animal Gates allow restricted access to compartments depending on time and Animal ID; (2) tubes (3) tunnels, and (4) stairways.
Every PhenoWorld setup is unique and is tailored to the specific needs of each customer. PhenoWorlds can be configured on one level or may extend across several levels adding further enrichment while saving space.
Features
- Integrates several modules
- Interconnectable with RFID-based AnimalGates
Applications
- Animal Welfare
- Cognition
- Phenotyping
- Social Behavior
Disease models
- Mood disorders
- Cognitive deficits
Selected Publicatons:
Castelhano-Carlos M, Aslani S, Sousa N. The impact of physical enrichment in the structure of the medial prefrontal cortex and nucleus accumbens of the adult male rat brain. Neuroscience 2021; 454: 51-60
Torquet N, Marti F, Campart C, Tolu S, Nguyen C, Oberto V, Benallaoua M, Naudé J, Didienne S, Debray N, Jezequel S, Le Gouestre L, Hannesse B, Mariani J, Mourot A, Faure P. Social interactions impact on the dopaminergic system and drive individuality. Nat Commun 2018; 9(1): 3081
Castelhano-Carlos M, Baumans V, Sousa N. PhenoWorld: addressing animal welfare in a new paradigm to house and assess rat behaviour. Lab Anim 2017; 51(1): 36-43
Castelhano-Carlos M, Costa PS, Russig H, Sousa N. PhenoWorld: a new paradigm to screen rodent behavior. Transl Psychiatry 2014; 4(6): e399
Selected Product Citations
PsyCoP – A Platform for Systematic Semi-Automated Behavioral and Cognitive Profiling Reveals Gene and Environment Dependent Impairments of Tcf4 Transgenic Mice Subjected to Social Defeat |
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| Paul Volkmann, Marius Stephan | Front Behav Neurosci | Published 14 Jan 2021 |
| Article Snippet Thus, we refer to the PsyCoP platform as partially or semi-automatized solution.. To overcome this limitation, handling could be further reduced in the future by connecting different types of cages into a so-called PhenoWorld setup, where transponder-responsive gates allow voluntary or controlled access of individual animals to different parts of the arena.. Thereby, different automated home cage systems such as conditioning boxes and the digital ventilated cages from Tecniplast could be combined with IntelliCages as suggested in a recent review (Voikar and Gaburro, ). |
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Assessing mouse behaviour throughout the light/dark cycle using automated in-cage analysis tools |
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| Rasneer S. Bains, Sara Wells, Patrick M. Nolan | J Neurosci Methods | Published 15 Apr 2018 |
| Article Snippet into this bespoke environment for the testing period. resolved this issue by adding an automated sorting system that allows individual animals to enter or leave a test arena from its home cage by triggering a gate with its RFID tag. … Phenoworld (TSE systems) combined the above two approaches and offers bespoke testing environments, where the animals are housed in the central IntelliCage chamber and this is connected to various testing arenas through AnimalGate, all data collection is fully automated and experimenter intervention is almost negligible.. Phenoworld (TSE systems) combined the above two approaches and offers bespoke testing environments, where the animals are housed in the central IntelliCage chamber and this is connected to various testing arenas through AnimalGate, all data collection is fully automated and.. |
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PhenoWorld: a new paradigm to screen rodent behavior |
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| M Castelhano-Carlos, P S Costa | Transl Psychiatry | Published 10 Jun 2014 |
| Article Snippet Modeling depression in animals has inherent complexities that are augmented by intrinsic difficulties to measure the characteristic features of the disorder.. Herein, we describe the PhenoWorld (PhW), a new setting in which groups of six rats lived in an ethological enriched environment, and have their feeding, locomotor activity, sleeping and social behavior automatically monitored.. A battery of emotional and cognitive tests was used to characterize the behavioral phenotype of animals living in the PhW and in standard conditions (in groups of six and two rats), after exposure to an unpredictable chronic mild stress paradigm (uCMS) and antidepressants. |
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| Figure Legend Home-cage behavior: ( a ) sleeping and locomotion; ( b ) interaction with objects; ( c ) self-maintenance (grooming+licking) behavior; and ( d ) social interaction divided in its different components (clump, social investigation, allogrooming and social play). Error bars represent s.e.m.; * P ⩽0.05 and ** P ⩽0.001 denote effects of housing; x P ⩽0.05 denote effects of stress. CMS, chronic mild stress; PhW, PhenoWorld. |
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